HOTAIR Expression and ECM Biomarkers in Takayasu Arteritis Patients

A clinical study dataset comparing long non-coding RNA HOTAIR expression and serum levels of nine extracellular matrix remodeling mediators between 53 patients with Takayasu arteritis and 53 matched healthy controls. The data was collected by Fernanda Espinosa-Bautista and published on figshare in April 2026. It includes quantified expression levels and protein concentrations measured via RT-qPCR and ELISA.

Use Cases

• Correlating lncRNA HOTAIR expression levels with circulating MMP and TIMP protein levels.
• Investigating the proteolytic profile associated with enhanced extracellular matrix turnover in Takayasu arteritis.
• Analyzing potential associations between reduced HOTAIR expression and MMP-mediated vascular injury.
• Comparing biomarker levels between patient and control cohorts for diagnostic or mechanistic studies.

Strengths

• Includes data from a matched cohort of 53 patients and 53 healthy controls.
• Measures 10 specific biological variables: HOTAIR expression and 9 serum protein concentrations.
• Provides statistical results including p-values and Spearman correlation coefficients for key relationships.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (673.5 KB), indicating limited scope.

Provenance

Source

figshare, author Fernanda Espinosa-Bautista.

Collection Method

Clinical study with patient recruitment; HOTAIR quantified by RT-qPCR, serum proteins by ELISA.

Time Range

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Freshness

Last updated 2026-04-16 05:18:50; freshness should be verified.

Geography

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