In Vitro Genotoxicity Assessment of a Novel Synthetic Fat

OECD-compliant in vitro assays evaluated a novel synthetic fat for mutagenic and clastogenic potential. The dataset contains results from bacterial reverse mutation, mammalian gene mutation, and micronucleus tests across multiple concentrations. Sydney Schreppler authored this study, which was last updated in April 2026.

Use Cases

• Compare revertant colony counts from the bacterial reverse mutation assay across different concentrations of SMLCT.
• Analyze mutant frequency data from L5178Y mouse lymphoma cells to assess gene mutation potential.
• Evaluate the frequency of micronucleated binucleated cells in human lymphocytes to determine clastogenic activity.
• Correlate test results from the three distinct OECD Test Guidelines (471, 490, 487) to form a comprehensive genotoxicity profile.

Strengths

• Data generated following three standardized OECD Test Guidelines (471, 490, 487).
• Tests conducted across a defined range of concentrations (e.g., up to 5000 µg/plate for bacterial assay).
• Includes results from multiple assay types targeting different genotoxic endpoints (mutation, clastogenicity).

Limitations

• Dataset is small in scale (678.7 KB), contained within a single document, limiting statistical re-analysis.
• Specific numerical results, sample sizes (n), and raw data points are not explicitly provided in the description.
• Findings are limited to in vitro conditions and may not directly predict in vivo effects.

Provenance

Source

Sydney Schreppler via figshare.

Collection Method

Experimental data from in vitro genotoxicity assays conducted per OECD guidelines.

Time Range

null

Freshness

Last updated in April 2026.

Geography

null