Integrative Genetic and Transcriptomic Study Linking Tuberculosis and Asthma

Five candidate genes, including CRLF2 and ETV5, were identified as potential biomarkers linking tuberculosis and asthma. This 1.1 MB Excel dataset contains results from a study using Mendelian randomization and transcriptomic analysis, authored by Yingxia Liu and last updated in May 2026. The work integrates global disease burden data from 2013-2023 with gene expression data from clinical cohorts.

Use Cases

• Validate candidate biomarker genes (CRLF2, ETV5, LRRC1, OR10H1, SENP2) for disease comorbidity based on the study's findings.
• Investigate causal relationships between pulmonary tuberculosis and asthma risk using the reported Mendelian randomization odds ratios.
• Analyze shared immune pathway activation and cellular function suppression in tuberculosis and asthma from the transcriptomic results.
• Assess the global disease burden comparison between tuberculosis and asthma from 2013 to 2023.

Strengths

• Includes results validated in an independent clinical cohort of 40 tuberculosis patients and 40 healthy controls.
• Reports specific genetic association metrics, such as an odds ratio of 1.74 for tuberculosis as a risk factor for asthma.
• Candidate biomarkers demonstrated high discriminatory potential, with an area under the curve of up to 1.0 in the discovery cohort.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific genetic and transcriptomic sources used.

Provenance

Source

figshare

Collection Method

Analysis of Global Burden of Disease data, two-sample Mendelian randomization, and transcriptomic data from the Gene Expression Omnibus database.

Time Range

Global burden analysis covers 2013 to 2023.

Freshness

Last updated 2026-05-18 22:01:29; freshness should be verified.

Geography

Global scope for burden analysis; clinical cohort location is unspecified.