Plasma Exosomal Protein Profiles for Intrahepatic Cholestasis of Pregnancy

SWATH proteomics data from plasma exosomes of 35 pregnant women, including 10 with moderate ICP, 10 with severe ICP, and 15 healthy controls. The dataset, created by Yuxuan Jiang and last updated in April 2026, contains lists of differentially expressed proteins identified in total and placenta-derived exosomes.

Use Cases

• Identify potential diagnostic biomarkers for ICP severity based on differentially expressed proteins.
• Analyze biological pathways involved in ICP pathogenesis based on bioinformatics results.
• Validate candidate hub proteins like HRG, VWF, and PIGR using the provided protein lists.
• Compare protein expression profiles between total exosomes and placenta-derived exosomes.

Strengths

• Includes data from 35 patient samples across three clinical groups.
• Identifies 109 and 46 differentially expressed proteins in two exosomal comparisons.
• Results are supported by Western blot verification of three key proteins.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 11.5 KB, indicating a limited scope of data.

Provenance

Source

figshare

Collection Method

Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:50; freshness should be verified.