Risk Factors for Hypothyroidism in Euthyroid Patients with Thyroid Autoantibodies

A multicenter retrospective cohort study by Xue Feng investigates risk factors for hypothyroidism progression in patients with positive thyroid autoantibodies. The dataset includes 669 patients from Nanjing, China, with a median follow-up of 3.0 years, where 155 progressed to hypothyroidism. It was last updated on 2026-05-18.

Use Cases

• Identify high-risk patients for hypothyroidism based on baseline TSH, FT4, and TPOAb levels.
• Validate the proposed TPOAb cutoff of 187 IU/mL for clinical risk stratification.
• Analyze the protective effect of age on hypothyroidism progression in this cohort.
• Build predictive models for hypothyroidism onset using demographic and thyroid function parameters.

Strengths

• Includes 669 patient records from a multicenter study.
• Follow-up data spans a median of 3.0 years.
• Identifies specific risk factors (age, TSH, FT4, TPOAb) with hazard ratios and confidence intervals.
• Proposes an optimized TPOAb cutoff (187 IU/mL) validated with AIC and C-index metrics.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the Nanjing cohort.

Provenance

Source

Author: Xue Feng. Platform: figshare.

Collection Method

Multicenter retrospective cohort study.

Time Range

Patients enrolled from January 2018 to December 2024.

Freshness

Last updated 2026-05-18 05:43:08; freshness should be verified.

Geography

Nanjing, China.