ANCA-Associated Vasculitis Cardiovascular Risk Study Results

A retrospective cohort study analyzing data from the US-based TriNetX network. The study includes 26,329 patients with granulomatosis with polyangiitis or microscopic polyangiitis and matched controls. It was authored by Sebastian Klapa and last updated in April 2026.

Use Cases

• Calculate hazard ratios for mortality and cardiovascular events based on the propensity-matched cohort methodology described.
• Compare cardiovascular risk profiles between GPA and MPA patient groups based on the reported hazard ratios.
• Model the association between ANCA-associated vasculitis and thromboembolic events based on the study's findings.
• Validate population-based database analyses for major adverse cardiovascular events in AAV based on the cohort results.

Strengths

• Includes a large cohort of 26,329 patients with AAV and matched controls.
• Uses propensity score matching for demographic variables and comorbidity to optimize comparability.
• Provides specific hazard ratios for outcomes like MACE, deep vein thrombosis, and pulmonary embolism.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the US-based TriNetX network source.

Provenance

Source

Electronic health records database of the US-based TriNetX network.

Collection Method

Retrospective cohort study with propensity score matching.

Time Range

null

Freshness

Last updated 2026-04 05:45:57; freshness should be verified.

Geography

United States (based on the TriNetX network source).