Androgen Profiles in Adolescent Girls with Polycystic Ovary Syndrome

Xuan Zhang's dataset on figshare contains clinical and laboratory data from a study of 37 adolescent PCOS patients and 22 age-matched healthy controls. The data includes steroid hormone levels measured via LC-MS/MS and results from dexamethasone suppression tests performed on a subset of 24 patients. The dataset was last updated on June 3, 2026.

Use Cases

• Identify diagnostic biomarkers for PCOS based on steroid hormone levels like DHEA-S, total testosterone, and androstenedione.
• Evaluate the performance of the Free Androgen Index (FAI) as a diagnostic marker using ROC analysis results.
• Investigate the adrenal versus ovarian origins of androgens using dexamethasone suppression test results.
• Analyze correlations between different androgen levels, such as the relationship between DHEA-S and 11-OHAD.

Strengths

• Includes data from 37 PCOS patients and 22 healthy controls, providing a case-control comparison.
• Uses liquid chromatography-tandem mass spectrometry (LC-MS/MS), a high-precision method for steroid profiling.
• Contains results from a dexamethasone suppression test for 24 patients, enabling analysis of androgen origin.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 88.6 KB, indicating limited scope.

Provenance

Source

figshare, author Xuan Zhang.

Collection Method

Consecutive enrollment of patients and controls, with clinical evaluation and LC-MS/MS steroid profiling.

Freshness

Last updated 2026-06-03 04:47:25; freshness should be verified.