ANPEP Gene Expression Data for Atherosclerotic Stroke Research

249.7 KB Excel file contains data from a multi-omics study investigating lysosome-related genes in large-artery atherosclerotic stroke. Fanghui Bai authored this dataset, which was last updated on April 24, 2026. The research identified ANPEP as a key regulator of macrophage lipid metabolism and foam cell formation.

Use Cases

• Validate ANPEP as a diagnostic biomarker for large-artery atherosclerotic stroke based on AUC performance metrics mentioned in the description
• Analyze macrophage subpopulation gene expression patterns, particularly in TREM2+ lipid-associated macrophages, as indicated by single-cell RNA sequencing data
• Investigate correlations between ANPEP expression and lipid transport genes like SPP1, CD36, and ABCA1 using pseudotime trajectory analysis
• Model the impact of ANPEP knockdown on foam cell formation and lipid deposition pathways, including VDR and MAPK signaling

Strengths

• Data is derived from multiple transcriptomic datasets (GSE100927 and GSE28829) and single-cell RNA sequencing data (GSE159677)
• Results include external validation cohort performance metrics (AUC: 0.803–1.000)
• Licensed under CC-BY-4.0 for open reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Integrated analysis of transcriptomic datasets, protein-protein interaction networks, and machine learning algorithms, followed by experimental validation.

Freshness

Last updated 2026-04-24 04:23:35; freshness should be verified