Anti-Arthritic Activities of Hydrogel Therapy in a Rat Gouty Arthritis Model

Jingya Zhao published experimental data on figshare in 2026 evaluating cross-linked hyaluronic acid-dexamethasone hydrogel treatments for gouty arthritis. The dataset likely contains behavioral, imaging, histological, and molecular biomarker results from a controlled rat study with four treatment groups of eight rats each. It includes measurements such as knee joint swelling, grip strength, pain thresholds, and expression levels of cytokines like IL-1β and TNF-α.

Use Cases

• Compare therapeutic efficacy of different hydrogel formulations based on behavioral indicators like weight-bearing capacity and gait scoring.
• Analyze correlations between molecular biomarkers (e.g., IL-6, MMP-3) and histological cartilage damage assessments.
• Evaluate the chondroprotective effect of combined therapy (cHA-Dex) versus monotherapy (cHA alone) based on imaging and staining results.

Strengths

• The study design includes a controlled comparison of four distinct treatment groups with eight rats per group.
• Assessment incorporates multiple data modalities: behavioral tests, imaging (micro X-ray), histology, and molecular assays (ELISA, RT-qPCR).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in scale at 670.1 KB, indicating limited data volume.

Provenance

Source

Jingya Zhao via figshare.

Collection Method

Data collected from a controlled laboratory experiment using a rat model of gouty arthritis induced by MSU/LPS injections.

Freshness

Last updated 2026-05-13 05:34:07; freshness should be verified.