Table 1_Anti-centromere protein B antibody positivity in primary Sjögren’s disease: clinic

A clinical cohort of 1,222 patients with primary Sjögren’s disease from the China–Japan Friendship Hospital, studied between February 2014 and February 2023 with follow-up through February 2024. The dataset compares clinical and immunological features between 100 anti-CENP-B antibody positive patients and 1,122 negative patients. It was created by Chunxin Lei and shared under a CC-BY-4.0 license.

Use Cases

• Compare clinical profiles (e.g., xerostomia, Raynaud's phenomenon) between antibody-positive and negative patient groups.
• Analyze associations between anti-CENP-B positivity and laboratory markers like platelet count, liver enzymes, and immunoglobulin levels.
• Investigate prognostic implications for outcomes like mortality, cancer, or interstitial lung disease based on antibody status.
• Conduct subgroup analysis comparing patients with isolated anti-CENP-B positivity to those with additional autoantibodies.

Strengths

• Includes 1,222 patient records from a single hospital cohort.
• Provides a clear comparison group with 100 anti-CENP-B positive and 1,122 negative patients.
• Follow-up data extends through February 2024 for a cohort studied from 2014-2023.
• Analysis includes multiple clinical, immunological, and outcome variables as described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for specific analyses (e.g., LSGB data) is unknown, which may limit suitability assessment.
• Data reflects a single-center study from China, which may limit generalizability.

Provenance

Source

China–Japan Friendship Hospital

Collection Method

Ambispective cohort study with serum testing for antibody categorization.

Time Range

Patient data from February 2014 to February 2023, with follow-up through February 2024.

Freshness

Last updated 2026-04-23 05:34:47; freshness should be verified.

Geography

China