Table 1_Anti-PD-1 blockade reverses low-intensity electric stimulation-driven pancreatic c

Mouse orthotopic pancreatic ductal adenocarcinoma models were used to evaluate immune modulation and macrophage polarization effects of low-intensity electric stimulation. The dataset includes results from flow cytometry, multicolor immunofluorescence, and single-cell RNA sequencing, generated by Lingmin Jiang and last updated on 2026-05-19. Anti-PD-1 blockade was found to reverse tumor growth and amplify CD8+ T cell activation in this context.

Use Cases

• Analyzing tumor immune microenvironment remodeling based on flow cytometry and multicolor immunofluorescence data
• Investigating epithelial-mesenchymal transition and cell migration based on in vitro assays under varying electric fields
• Studying macrophage polarization and CD8+ T cell activation based on single-cell RNA sequencing results
• Validating the JAK2-STAT3 pathway activation and PD-L1 expression based on bulk RNA sequencing analysis

Strengths

• Data includes results from multiple profiling techniques: flow cytometry, multicolor immunofluorescence, and single-cell RNA sequencing.
• The study utilizes orthotopic PDAC mouse models, which are described as being used for the first time to evaluate these specific effects.
• The underlying mechanism was investigated via bulk RNA sequencing and validated in vitro.

Limitations

• Dataset size is only 46.1 KB, indicating a very limited scope of data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data generated from orthotopic PDAC mouse models treated with LIES and anti-PD-1 blockade, with in vitro assays and sequencing analyses.

Freshness

Last updated 2026-05-19 05:40:21