Antibiotic Resistance in Aeromonas Hydrophila Exposed to Subtherapeutic Oxytetracycline

Three independent bacterial lineages rapidly developed oxytetracycline resistance after 3 days of exposure. Whole-genome sequencing identified recurrent point mutations in genes AHA_2785, AHA_2910, and AHA_0308, while transcriptomic analysis revealed over 1,000 differentially expressed genes. The dataset, authored by Ju Zhang and last updated in May 2026, likely contains genetic and transcriptional data from this experiment on antimicrobial resistance in aquaculture.

Use Cases

• Analyzing patterns of bacterial adaptation to incremental antibiotic doses based on the described exposure experiment.
• Identifying genetic markers for oxytetracycline resistance based on the recurrent point mutations mentioned in genes AHA_2785, AHA_2910, and AHA_0308.
• Studying coordinated changes in efflux pump, outer membrane protein, and ribosomal protein pathways based on the transcriptomic results.
• Modeling the development of antimicrobial resistance in aquatic environments based on the combined genetic and transcriptional data.

Strengths

• Includes data from whole-genome sequencing identifying specific recurrent mutations.
• Transcriptomic analysis covers over 1,000 differentially expressed genes.
• Data is licensed under CC-BY-4.0, permitting open reuse and modification.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 8.1 MB file size suggests a relatively small dataset.

Provenance

Source

figshare

Collection Method

Genetic and transcriptional monitoring of Aeromonas hydrophila exposed to incremental doses of oxytetracycline.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026-05-08 05:30:16; freshness should be verified.

Geography

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