Systematic Review of Intracanal Medicaments Against Enterococcus Faecalis

A 2026 systematic review and meta-analysis by Carlos M. Ardila, following PRISMA 2020 guidelines, synthesizes evidence on antimicrobial effectiveness against E. faecalis in endodontics. The review includes 12 studies from PubMed/MEDLINE, Scopus, and Embase, employing a structured domain-based interpretative synthesis. It compares antibiotic-based medicaments, calcium hydroxide, and novel agents, with quantitative pooling limited to two studies due to high heterogeneity.

Use Cases

• Compare the antimicrobial performance of different intracanal medicament formulations based on the synthesized review findings.
• Identify patterns of bacterial resistance and tolerance to common treatments as discussed in the interpretative synthesis.
• Assess the evidence quality and heterogeneity in endodontic in vitro and clinical studies as reported in the meta-analysis results.

Strengths

• Follows PRISMA 2020 guidelines for systematic review methodology.
• Includes 12 eligible studies from three major biomedical databases (PubMed/MEDLINE, Scopus, Embase).
• Employs a structured domain-based interpretative synthesis across key domains.

Limitations

• Quantitative meta-analysis was limited to only two studies, resulting in imprecise estimates.
• The overall certainty of evidence is reported as ranging from low to moderate.
• Column-level documentation is absent; the dataset is a 14.4 KB DOCX document, and its internal structure must be inspected after download.

Provenance

Source

Carlos M. Ardila via figshare.

Collection Method

Systematic literature review following PRISMA 2020 guidelines.

Freshness

Last updated 2026-05-29 06:07:44.