ANXA2-NLRP3 Pathway Data from Mouse Intracerebral Hemorrhage Study

A 9.9 MB Excel dataset from a 2026 figshare upload by Qingyuan Wu. It contains results from an integrative transcriptomic-proteomic profiling study of mouse intracerebral hemorrhage brain tissues. The data likely includes measurements related to ANXA2 expression, NLRP3 inflammasome activation, and neuronal pyroptosis.

Use Cases

• Validate hub protein identification based on multi-omics and network analyses described in the study.
• Analyze the association between ANXA2 and NLRP3 based on co-immunoprecipitation results.
• Model the impact of ANXA2 silencing on neurological function and brain pathology outcomes.
• Correlate inflammasome activation markers with histological and behavioral test data.

Strengths

• Dataset is 9.9 MB, indicating a substantial amount of structured data.
• Results are derived from integrative transcriptomic-proteomic profiling, suggesting a multi-modal approach.
• Includes in vivo functional validation data as described in the methods.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• Data is from a specific mouse model study; applicability to human stroke pathology may require validation.

Provenance

Source

figshare

Collection Method

Integrative transcriptomic-proteomic profiling of mouse ICH brain tissues with in vivo functional validation.

Freshness

Last updated 2026-05-26 04:39:07; freshness should be verified.