Mouse Brain Metabolomic and Lipidomic Profiles Across Menopause by APOE Genotype

Metabolomic and lipidomic profiles from the brains of humanized female mice with APOE3/3, APOE3/4, and APOE4/4 genotypes. The data was collected across chronological and endocrinological stages from pre- to postmenopause to investigate metabolic adaptation. The dataset was authored by Tian Wang, shared under a CC-BY-4.0 license, and last updated on June 2, 2026.

Use Cases

• Modeling the impact of APOE4 on brain metabolic pathways during menopause based on metabolomic profiles.
• Investigating the relationship between amino acid depletion and postmenopausal bioenergetic demand described in the results.
• Analyzing lipid accumulation and composition changes in the brain linked to APOE genotype.
• Studying the disruption of the tricarboxylic acid (TCA) cycle in the context of genetic risk for Alzheimer's disease.

Strengths

• Data includes multiple APOE genotypes (APOE3/3, APOE3/4, APOE4/4) for comparative analysis.
• Profiles were taken across distinct biological stages from pre- to postmenopause.
• The dataset is shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is small at 96.4 KB, indicating limited scope or a summary table.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare

Collection Method

Brain metabolomic and lipidomic profiling conducted on humanized female mice.

Freshness

Last updated 2026-06-02 05:42:36; freshness should be verified.