Assessing Translational Relevance of Molecular Pathways in Spontaneous Lupus Mouse Models

María Rivas-Torrubia's study provides longitudinal molecular data from four spontaneous lupus mouse models. The dataset includes transcriptome sequencing from blood, spleen, and kidney, flow cytometry, and plasma cytokine and autoantibody measurements at four time points. It was last updated on May 13, 2026, and integrates with human SLE cohort data to evaluate pathway-level similarities.

Use Cases

• Compare molecular pathway dysregulation across different spontaneous lupus mouse models based on transcriptome and flow cytometry data.
• Identify time points of interest for experimental design based on the dynamics of phenotype-associated molecular signatures described in the study.
• Assess the translational relevance of mouse models by comparing identified immune pathways with those observed in human SLE cohorts.
• Investigate relationships between specific molecular signatures, such as interferon responses or age-associated B cells, and disease activity or severity.

Strengths

• Includes data from four distinct spontaneous lupus mouse models (MRL lpr/lpr, NZB/W, BXSB.Yaa, Tlr7.Tg6) enabling comparative analysis.
• Provides longitudinal molecular profiling across four time points, capturing disease dynamics.
• Integrates multi-modal data types: transcriptome sequencing, flow cytometry, and plasma cytokine/autoantibody measurements.
• Dataset is openly available under a CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The primary data file is a 5.7 MB DOCX document, which may require parsing to extract structured data.

Provenance

Source

figshare, authored by María Rivas-Torrubia.

Collection Method

Experimental data from mouse models including transcriptome sequencing, flow cytometry, and plasma assays, integrated with human cohort data.

Freshness

Last updated 2026-05-13 05:58:05; freshness should be verified.