APTw MRI Biomarkers for Prostate Cancer Diagnosis and Gleason Score Correlation

Encompassing quantitative results from a study of 160 patients (86 with prostate cancer, 74 with benign prostatic hyperplasia) who underwent 3.0T multi-parametric MRI, including amide proton transfer-weighted (APTw) imaging. It compares APTw values with Apparent Diffusion Coefficient (ADC) values and PI-RADS v2.1 scores, and assesses the correlation between APTw values and Gleason Score (GS).

Use Cases

• Train a classifier to differentiate prostate cancer (PCa) from benign prostatic hyperplasia (BPH) using APTw values and PI-RADS v2.1 scores.
• Analyze the correlation between APTw values and Gleason Score (GS) for tumor aggressiveness assessment.
• Evaluate diagnostic performance of APTw imaging in the PSA 'gray zone' (4–10 ng/mL) compared to serum PSA.
• Build a combined model using APTw values and PI-RADS v2.1 scores to predict high-risk (GS ≥ 8) prostate cancer.

Strengths

• Data from 160 patients provides a basis for comparative analysis between PCa and BPH groups.
• Includes results for challenging clinical subgroups, such as lesions in the Transition Zone (TZ) and patients in the PSA 'gray zone'.
• Quantitative metrics like AUC values (e.g., 0.915 for combined model) and Spearman's ρ (0.407) are reported for diagnostic performance and correlation.

Limitations

• The dataset is small at 9.9 KB, indicating limited scope and likely a summary table rather than raw patient-level data.
• Sample data and column definitions are unavailable, limiting detailed feature analysis and reproducibility.
• As a retrospective study, the data may reflect specific patient selection criteria and imaging protocols from a single institution.

Provenance

Source

figshare, authored by Jie Feng.

Collection Method

Retrospective study where 160 patients underwent 3.0T multi-parametric MRI, including APTw imaging.

Freshness

Last updated on 2026-03-20.