Thyroid Nodule Malignancy Risk Associated with Circadian Rhythm Disruption

A propensity score-matched study of 2,541 patients who underwent thyroidectomy between 2016 and 2019 investigates the link between cumulative circadian rhythm disruption and thyroid cancer. The dataset likely contains patient-level data, including a novel circadian rhythm disruption index, histopathological diagnoses, and clinicopathological features. The research was authored by Pengfei Gu and shared under a CC-BY-4.0 license.

Use Cases

• Assessing malignancy risk based on a cumulative circadian rhythm disruption index.
• Investigating associations between lifestyle factors and aggressive tumor features like lymph node metastasis.
• Training predictive models for thyroid cancer aggressiveness using patient questionnaire and clinical data.

Strengths

• Study includes 2,541 patient records with propensity score matching to control for confounders.
• Analysis shows strong, dose-dependent odds ratios for malignancy risk across CRD severity levels.
• Dataset links circadian disruption to specific aggressive features, including a 69.4% lymph node metastasis rate in the High CRD group.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the final matched cohort is specified (1,700 patients), but the full data structure is unknown.
• The 16.5 KB file size suggests the dataset is a summary document rather than raw patient-level records.

Provenance

Source

figshare

Collection Method

Hospital-based study using preoperative questionnaires and postoperative histopathology.

Time Range

Data collected from patients between 2016 and 2019.

Freshness

Last updated 2026-05-12 04:19:25; freshness should be verified.