Table 1_Association between circulating biomarkers of one-carbon metabolism and glymphatic

A study of 210 participants, including individuals with normal cognition, mild cognitive impairment due to Alzheimer's disease, and Alzheimer's dementia. The dataset, authored by Yali Chen and last updated in May 2026, measures circulating biomarkers of one-carbon metabolism and a neuroimaging index of glymphatic function to explore their association with cognitive performance.

Use Cases

• Correlating serum folate levels with glymphatic function based on the DTI-ALPS index
• Comparing biomarker levels and cognitive scores across diagnostic groups (NC, AD-MCI, AD-D)
• Investigating sex-specific differences in metabolic and glymphatic markers
• Modeling the combined risk of low folate and low DTI-ALPS index on memory and processing speed

Strengths

• Includes data from 210 participants across three diagnostic stages of Alzheimer's disease
• Combines biochemical serum measurements (folate, B12, homocysteine) with a neuroimaging-derived metric (DTI-ALPS index)
• Reports statistically significant correlations (e.g., folate and DTI-ALPS index, r=0.212) and group differences

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small (12.0 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Clinical study enrolling participants and performing serum assays and neuroimaging.

Freshness

Last updated 2026-05-11 04:29:29; freshness should be verified