Meta-Analysis of Frailty and Delirium Risk After TAVR, 7,702 Patients

10 cohort studies involving 7,702 patients were included in this meta-analysis. The analysis found frailty was significantly associated with a 2.17 times higher odds of postoperative delirium after transcatheter aortic valve replacement. The dataset, a DOCX document by Zhiheng Liu, was last updated on 2026-05-21.

Use Cases

• Validate the association between frailty and postoperative delirium based on the pooled odds ratio of 2.17.
• Investigate heterogeneity sources in clinical studies based on the reported I² statistic of 55% and meta-regression results.
• Compare diagnostic method impact on effect size based on the stronger association found with CAM-ICU versus DSM criteria.
• Support perioperative risk stratification model development based on the conclusion highlighting the importance of frailty assessment.

Strengths

• Includes data from 10 cohort studies with a total of 7,702 patients.
• Reports specific pooled effect estimates (OR: 2.17, 95% CI: 1.60–2.95) and heterogeneity metrics (I² = 55%).
• Conducted subgroup analyses by sample size, study design, and diagnostic methods, providing detailed comparative results.

Limitations

• The dataset is a 17.9 KB DOCX document; the underlying raw study data is not provided, limiting direct analysis.
• Row count and column-level documentation for any underlying data tables are unknown.
• Freshness should be verified; the last update date is 2026-05-21, which is in the future relative to the current date.

Provenance

Source

Systematic search of PubMed, Embase, and Web of Science from inception to January 22, 2026.

Collection Method

Meta-analysis of included cohort studies using a random-effects model.

Time Range

Studies from database inception to January 2026.

Freshness

Last updated 2026-05-21 05:42:29