Oral Microbiome Diversity and Liver Disease Risk in U.S. Adults, 2009-2012

2,759 U.S. adults from the 2009-2012 NHANES survey, with 183 identified cases of Metabolic dysfunction-associated steatotic liver disease (MASLD). The dataset, authored by Zeru Liu, associates oral microbial diversity metrics with MASLD risk using survey-weighted logistic regression. It was last updated on June 2, 2026.

Use Cases

• Training predictive models for liver disease risk based on microbiome diversity indices mentioned in the description.
• Conducting stratified epidemiological analysis based on body mass index and smoking status subgroups.
• Investigating dose-response relationships between microbial community composition and clinical outcomes.
• Benchmarking microbiome diversity metrics (e.g., Shannon-Wiener Index) against a large, population-based cohort.

Strengths

• Includes 2,759 individual records from a nationally representative survey (NHANES).
• Analysis is based on sequenced oral rinse samples targeting the 16S rRNA V4 region.
• Uses multiple established alpha and beta diversity metrics (Observed OTUs, Faith's PD, Bray-Curtis).
• Findings are adjusted for demographic, lifestyle, and clinical metabolic covariates.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying analysis data is unknown, which may limit suitability assessment.
• The primary file is a 31.3 KB DOCX document, suggesting the dataset scope is limited to summary results.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES)

Collection Method

Population-based retrospective study using survey data and 16S rRNA sequencing of oral rinse samples.

Time Range

2009 to 2012

Freshness

Last updated 2026-06-02 04:21:34; freshness should be verified.

Geography

United States