Oral Microbiome Diversity and Liver Disease Risk in 2,759 U.S. Adults

Zeru Liu's study, last updated in 2026, analyzes the association between oral microbial diversity and Metabolic dysfunction-associated steatotic liver disease (MASLD) risk. The dataset includes 2,759 U.S. adults from the 2009-2012 National Health and Nutrition Examination Survey (NHANES), with 183 identified MASLD cases. It contains survey-weighted analyses of alpha and beta diversity metrics from oral rinse samples.

Use Cases

• Modeling MASLD risk based on oral microbial diversity metrics described in the study.
• Analyzing dose-response relationships between bacterial diversity groups and disease likelihood.
• Stratifying risk associations by body mass index and smoking status as performed in the original analysis.
• Comparing overall bacterial community makeup between individuals with and without MASLD.

Strengths

• Includes 2,759 individual records from a nationally representative survey (NHANES).
• Analysis is stratified by body mass index and smoking status, allowing for subgroup investigation.
• Uses multiple established alpha diversity indices (Observed OTUs, Faith’s Phylogenetic Diversity, Shannon-Wiener, Inverse Simpson) and beta diversity measures (Bray-Curtis, UniFrac).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying analysis data is unknown, which may limit suitability assessment.
• The 31.3 KB file size suggests the dataset likely contains summary or processed results, not raw sequence data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) 2009-2012.

Collection Method

Population-based retrospective study using oral rinse samples sequenced for the 16S rRNA V4 region.

Time Range

2009 to 2012

Freshness

Last updated 2026-06-02 04:28:26; freshness should be verified.

Geography

United States