Physical Activity and Inflammatory Bowel Disease Risk in UK Biobank Cohort

UK Biobank data from 293,578 participants was used in a prospective cohort study to evaluate the longitudinal relationship between physical activity intensity and the incidence of Crohn's disease and ulcerative colitis. The dataset contains results from multivariable Cox regression models and restricted cubic spline analyses examining this association. It was authored by Yitian Wei and last updated on May 14, 2026.

Use Cases

• Assessing the association between light, moderate, and vigorous physical activity levels and Crohn's disease risk based on self-reported activity data.
• Investigating potential non-linear relationships between physical activity intensity and ulcerative colitis incidence using restricted cubic spline curves.
• Comparing disease progression over time between activity level groups using cumulative event curves.
• Evaluating the protective effect of activity exceeding standard health recommendations on ulcerative colitis risk within specific subpopulations.

Strengths

• Large prospective cohort of 293,578 participants from the UK Biobank.
• Incident IBD cases were identified through linked hospital admission and death registry records.
• Analysis includes multivariable Cox proportional hazards regression models and restricted cubic spline curves.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the UK Biobank source.

Provenance

Source

UK Biobank

Collection Method

Prospective cohort study analyzing self-reported physical activity data and linked hospital/death records.

Freshness

Last updated 2026-05-14 05:23:54; freshness should be verified.

Geography

United Kingdom