aMAP Risk Score and Mortality in MASLD/MetALD/ALD Patients: NHANES 1999-2018 Cohort

32,654 participants from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were analyzed to assess the aMAP risk score's association with mortality. The study, authored by Peng-yang Li and updated in 2026, found the aMAP score is independently linked to higher all-cause, cardiovascular, and cancer mortality across steatotic liver disease subgroups. An external validation cohort of 642 Southern Chinese patients was also included.

Use Cases

• Validate the aMAP risk score for mortality prediction based on the described cohort study results.
• Analyze non-linear relationships between risk scores and mortality using the described Restricted Cubic Spline methods.
• Conduct competing risk analyses for cause-specific mortality based on the described Fine-Grey model application.
• Perform external validation of clinical risk scores using independent hospital-based cohorts as described.

Strengths

• Includes a large primary cohort of 32,654 participants from a national survey.
• Provides external validation with an independent cohort of 642 patients.
• Analyzes multiple mortality outcomes: all-cause, cardiovascular, and cancer.
• Uses a clear multivariable adjustment methodology as described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary data table is unknown, which may limit suitability assessment.
• The dataset is very small (18.2 KB), suggesting it may contain summary results rather than raw patient-level data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) and an independent hospital-based Southern Chinese cohort.

Collection Method

Cohort study using multivariable Cox proportional hazards models and competing risk analyses.

Time Range

NHANES data from 1999 to 2018, with mortality follow-up through December 31, 2019.

Freshness

Last updated 2026-04-24 13:49:20; freshness should be verified.

Geography

United States (NHANES) and Southern China (validation cohort).