Zinc Deficiency and Dementia Outcomes: 2,482 Matched Patient Records

Aggregating 2,482 matched patient records from a retrospective cohort study investigating zinc deficiency in dementia patients. It analyzes associations between serum zinc levels and clinical outcomes like 1-year mortality, sepsis, and ICU admission. The study uses data from the TriNetX Research Network for patients diagnosed between 2010 and 2024.

Use Cases

• Analyze the association between serum zinc measurement categories (<70 μg/dL vs. 70–120 μg/dL) and 1-year all-cause mortality.
• Investigate dose–response relationships by modeling severe zinc deficiency (<50 μg/dL) against sepsis risk and mortality hazard ratios.
• Examine secondary outcomes like intensive care unit admission, urinary tract infection, and elevated C-reactive protein levels across zinc status cohorts.
• Perform subgroup or sensitivity analyses on the matched cohort data to assess the robustness of the primary findings over 1–3 years of follow-up.

Strengths

• Study includes 2,482 matched patient records (1,241 per cohort), providing a clear comparison group.
• Analysis covers multiple specific clinical outcomes with reported hazard ratios and p-values (e.g., mortality HR 1.54, sepsis HR 1.76).
• Dataset includes dose–response analysis for severe zinc deficiency (<50 μg/dL), showing a mortality HR of 1.85 and sepsis HR of 2.92.

Limitations

• Dataset is small (18.3 KB), likely containing summary results rather than raw patient-level data, limiting analytical flexibility.
• As an observational study, the findings show association but not causation, with attenuated effects over extended follow-up (1–3 years).
• Specific column definitions and raw data rows are unknown, restricting direct reuse for modeling.

Provenance

Source

TriNetX Research Network

Collection Method

Retrospective matched cohort study using electronic health records.

Time Range

January 2010 to December 2024

Freshness

Data covers patients diagnosed up to December 2024, with the dataset last updated in March 2026.

Geography

United States (inferred from tags)