18 individuals were enrolled in a study investigating genetic predisposition to multisystem inflammatory syndrome in children (MIS-C). The dataset likely contains results comparing the frequency of ABO tagging SNPs and rare variants in immune-related genes between patients and controls. The data was published by Luisa Ronzoni on figshare in April 2026.
Use Cases
- Assessing the association between blood group B alleles and MIS-C risk based on odds ratios reported.
- Investigating the role of rare damaging variants in immune-related genes in MIS-C development.
- Comparing genetic susceptibility between MIS-C and Kawasaki disease subphenotypes.
- Analyzing the frequency of GWAS-prioritized loci for COVID-19 severity in pediatric cohorts.
Strengths
- Includes data from 18 enrolled individuals and comparisons with 79 pediatric and 2,848 adult controls.
- Contains statistically significant odds ratios (e.g., 2.9 for MIS-C, 6.8 for KD subphenotype).
- Results are based on whole exome sequencing of a panel of 207 immune-related genes.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is very small (31.8 KB), indicating limited scope.
Provenance
- Source
- figshare, authored by Luisa Ronzoni.
- Collection Method
- Genetic analysis comparing patients with MIS-C and Kawasaki disease to controls.
- Freshness
- Last updated 2026-04-10 06:02:05; freshness should be verified.
- Geography
- Italian cohort.