Blood Urea Nitrogen to Albumin Ratio and Cerebral Small Vessel Disease in 762 Participants

762 participants, including 452 patients with cerebral small vessel disease (CSVD), were analyzed in a cross-sectional study by Qian Luo. The dataset likely contains clinical, hematological, and neuroimaging results used to assess the association between the blood urea nitrogen to albumin ratio (BAR) and CSVD markers. The study found BAR was positively associated with CSVD, white matter hyperintensities, and enlarged perivascular spaces, with results published on figshare in 2026.

Use Cases

• Train a model to predict cerebral small vessel disease risk based on the blood urea nitrogen to albumin ratio (BAR) and other clinical factors.
• Analyze the dose-response relationship between BAR and specific ischemic neuroimaging markers like white matter hyperintensities (WMH).
• Conduct a sensitivity analysis to test the robustness of biomarker associations against varying levels of kidney function.
• Evaluate model performance for CSVD classification using metrics like AUC, as demonstrated in the study's ROC analysis.

Strengths

• Includes data from 762 participants, providing a substantive sample size for analysis.
• Study design employed multiple statistical methods, including multivariable logistic regression and restricted cubic splines, suggesting methodological rigor.
• Results include specific odds ratios and confidence intervals (e.g., OR: 1.77 for CSVD), allowing for quantitative validation.
• Sensitivity analyses were conducted to confirm associations were robust against varying kidney function.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain modeling tasks.
• The cross-sectional design limits the ability to infer causal relationships from the data.

Provenance

Source

Qian Luo via figshare.

Collection Method

Clinical data, hematological markers, and neuroimaging results were collected from 762 participants in a cross-sectional study.

Freshness

Last updated 2026-05-21 14:00:00; freshness should be verified.