Serum Active IL-18 Levels and Clinical Features in Adult-Onset Still's Disease

Shuhei Yoshida's study, last updated April 2026, provides data on serum active interleukin-18 levels in patients with adult-onset Still's disease. The dataset includes measurements from 47 untreated AOSD patients, 42 rheumatoid arthritis patients, 9 familial Mediterranean fever patients, and 26 healthy controls. It correlates active IL-18 with clinical parameters, cytokine profiles, and diagnostic scores.

Use Cases

• Diagnostic model development based on the reported active IL-18 cutoff of >4,231.1 pg/mL for AOSD.
• Correlation analysis between cytokine levels and clinical features like rash and splenomegaly mentioned in the description.
• Biomarker validation for disease activity tracking using the reported associations with Pouchot score, ferritin, and C-reactive protein.

Strengths

• Includes data from 124 total subjects across four distinct cohorts (AOSD, RA, FMF, healthy controls).
• Reports specific diagnostic performance metrics, including 89.4% sensitivity and 92.9% specificity for active IL-18.
• Correlates a primary biomarker with 69 other cytokines and multiple clinical scores as described.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 16.5 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Serum samples were analyzed using specific ELISA and multiplex suspension arrays as described in the study methods.

Freshness

Last updated 2026-04-28 05:24:17; freshness should be verified.