FCRL3 Gene Variants and Rheumatoid Arthritis Risk in an Indian Population

Indian population data from a case-control study of 226 rheumatoid arthritis patients and 239 controls. The dataset likely contains genotyping results for four FCRL3 gene SNPs and associated statistical analyses, authored by Mohamed Muzammil S and last updated in June 2026. The study includes in-silico molecular docking and dynamics simulations to explore variant impact.

Use Cases

• Assessing genetic association signals based on odds ratios and p-values for specific SNPs.
• Conducting gender-stratified analyses of disease risk using the described statistical methods.
• Validating in-silico molecular docking predictions (e.g., HADDOCK scores) with clinical genotype data.
• Investigating population-specific genetic risk factors for rheumatoid arthritis.

Strengths

• Includes data from 465 total subjects (226 cases, 239 controls) providing a defined sample size.
• Reports specific statistical results, such as an adjusted odds ratio of 2.03 for the rs7522061 variant.
• Combines wet-lab genotyping (High-Resolution Melting Analysis) with computational validation (Sanger sequencing, molecular dynamics).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is limited to a single Indian population cohort, which may affect generalizability.

Provenance

Source

figshare

Collection Method

Genotyping via High-Resolution Melting Analysis and Sanger sequencing, with statistical and in-silico computational analysis.

Freshness

Last updated 2026-06-03 08:04:31; freshness should be verified.

Geography

Indian population