Table 1_Association of logarithmic lymphocyte-albumin product with active tuberculosis in

1,080 participants under 18 years old were included in a retrospective study investigating a novel biomarker for active tuberculosis (ATB). The research, authored by Jinyu Chen and last updated in April 2026, compares ATB patients (n=904) to non-TB controls (n=176) using the logarithmic lymphocyte-albumin product (logLAP). Results indicate logLAP levels were significantly lower in ATB patients and the biomarker showed an area under the curve (AUC) of 0.6955 in diagnostic analysis.

Use Cases

• Training a binary classification model to predict active tuberculosis based on the logLAP biomarker.
• Benchmarking the diagnostic performance of logLAP against traditional biomarkers like NLR, PLR, and PNI.
• Investigating non-linear relationships and threshold effects between immune-nutritional biomarkers and disease status.
• Conducting stratified analysis to assess biomarker performance across different age or immune function subgroups.

Strengths

• Dataset includes 1,080 pediatric and adolescent participants, providing a substantial sample for analysis.
• Study reports specific performance metrics, including an AUC of 0.6955 and a diagnostic cut-off value of 4.23 for logLAP.
• Analysis is comprehensive, employing ROC curves, logistic regression, restricted cubic splines, and stratified subgroup tests.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data table is unknown, which may limit suitability assessment.
• The authors note the diagnostic performance of logLAP remained relatively limited, suggesting it is a supplementary tool.

Provenance

Source

Jinyu Chen, via figshare.

Collection Method

Retrospective study of clinical participants.

Time Range

The study period is not specified in the provided metadata.

Freshness

Last updated 2026-04-14 14:16:45; freshness should be verified.

Geography

Geographic coverage is not specified in the provided metadata.