Table 1_Association of NDRG4 gene methylation in peripheral blood leukocytes with gastric

310 gastric cancer patients and 300 controls were analyzed in a two-phase case-control study to investigate the association between NDRG4 gene methylation in peripheral blood leukocytes and gastric cancer risk, chemotherapy efficacy, and prognosis. The dataset includes results from bioinformatics analysis of NDRG family genes using TCGA and GEO databases, as well as comparisons of methylation levels across rs7202037 SNP genotypes. It was authored by Zhan Li and last updated on 2026-04-27.

Use Cases

• Identifying epigenetic biomarkers for gastric cancer risk based on NDRG4 gene methylation sites.
• Predicting chemotherapy efficacy in gastric cancer patients using methylation levels at specific CpG sites.
• Analyzing the association between gene methylation and progression-free survival (PFS) in cancer prognosis.
• Investigating the relationship between single nucleotide polymorphism (SNP) rs7202037 genotypes and gene methylation levels.

Strengths

• Includes data from 610 total participants (310 patients, 300 controls) across two study phases.
• Reports specific statistical associations, such as an odds ratio of 2.536 for the NDRG4-chr16:58497239 site with gastric cancer risk.
• Integrates findings from established public databases (TCGA and GEO) with original case-control data.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 13.9 KB, indicating limited scope, likely containing summary results rather than raw individual-level data.

Provenance

Source

figshare

Collection Method

Bioinformatics analysis of public databases (TCGA, GEO) combined with a two-phase case-control study.

Freshness

Last updated 2026-04-27 04:12:22; freshness should be verified.