NHHR Lipid Biomarker Association with Mortality in Elderly CKM Patients

424,648 participants aged ≥65 years from the Guangzhou Older Longitudinal Dynamic Health Cohort were analyzed over a median follow-up of 4.93 years. The study examines the U-shaped association between the NHHR lipid ratio and risks of all-cause and cardio-cerebrovascular disease mortality. Suqi Xu authored this cohort study, which was registered under ChiCTR2400089945.

Use Cases

• Analyze mortality risk associations based on NHHR quartiles.
• Investigate nonlinear (U-shaped) relationships between lipid ratios and health outcomes.
• Perform mediation analysis based on the role of estimated pulse wave velocity.
• Study cardio-cerebrovascular disease mortality in an elderly cohort.
• Validate novel lipid biomarkers for clinical risk assessment.

Strengths

• The cohort includes 424,648 participants, providing a substantial sample size.
• Median follow-up period of 4.93 years offers longitudinal data.
• Results include specific hazard ratios and confidence intervals for mortality outcomes.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data is specific to elderly patients in Guangzhou, which may limit generalizability.

Provenance

Source

Guangzhou Older Longitudinal Dynamic Health Cohort.

Collection Method

Cohort study employing Cox models and restricted cubic splines.

Freshness

Last updated 2026-05-29 04:44:02; freshness should be verified.

Geography

Guangzhou, China.