Serum Periostin Associations with Bone and Muscle Health in Postmenopausal Women

135 Chinese postmenopausal women were assessed for serum periostin levels and its correlations with bone density, microarchitecture, muscle mass, and physical function. The dataset contains clinical and biomarker measurements from a cross-sectional study by Yiyi Gong, published in 2026. It includes parameters from DXA, HR-pQCT scans, and physical performance tests.

Use Cases

• Analyze correlations between serum_periostin levels and bone microarchitecture parameters like total_area, cortical_perimeter, and trabecular_area.
• Model the relationship between serum_periostin and muscle metrics such as appendicular_skeletal_muscle_mass and handgrip_strength.
• Predict fall risk scores like FROP_Com or Timed_Up_and_Go time using serum_periostin and other clinical measurements.
• Investigate associations between serum_periostin and estimated bone strength parameters stiffness and failure_load.

Strengths

• Includes 135 patient records with a comprehensive set of clinical assessments.
• Contains multi-modal measurements: biomarker (serum periostin), imaging (DXA, HR-pQCT), and physical function tests.
• Mean serum periostin level (1770.3 ± 440.4 pmol/L) provides a clear baseline for the cohort.

Limitations

• Small sample size of 135 limits statistical power and generalizability.
• Single geographic cohort (Chinese women) introduces population bias.
• Cross-sectional design prevents analysis of causal relationships or longitudinal changes.

Provenance

Source

Yiyi Gong via figshare.

Collection Method

Clinical study measuring serum periostin, DXA scans, HR-pQCT imaging, and physical performance tests.

Time Range

Study period not specified; dataset published in 2026.

Freshness

Data last updated in April 2026.

Geography

Community-dwelling Chinese postmenopausal women.