Association of Glucose Metabolism with Tear-Film Stability and Secretion in 300 Adults

Huan Xiang's dataset presents results from a single-center cross-sectional study of 300 adults, conducted from April 2024 to March 2025. It examines the graded association between glycemic status (non-diabetes, prediabetes, diabetes) and ocular surface parameters, including tear break-up time, Schirmer test results, and dry eye disease prevalence. The data includes adjusted statistical analyses for multiple covariates.

Use Cases

• Modeling the relationship between HbA1c levels and tear break-up time based on the continuous glucose metrics described.
• Predicting dry eye disease odds based on glycemic strata and measured ocular signs.
• Analyzing the correlation between glucose markers and inflammatory signs like tear osmolarity and MMP-9 positivity.
• Comparing the effects of fasting plasma glucose versus HbA1c on ocular outcomes as mentioned in the results.

Strengths

• Includes data from 300 adults, with 100 participants per glycemic stratum.
• Study design adjusted for prespecified demographic, clinical, and environmental covariates.
• Reports multiple co-primary and secondary outcomes, including NIBUT, Schirmer I, OSDI, and osmolarity.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data is from a single-center cross-sectional study, which may limit generalizability.
• The dataset is very small at 21.6 KB, indicating limited scope.

Provenance

Source

Huan Xiang via figshare.

Collection Method

Single-center cross-sectional study with quota sampling.

Time Range

April 2024 to March 2025.

Freshness

Last updated 2026-04-13 04:35:30; freshness should be verified.

Geography

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