TyG Index Association with Sepsis Outcomes in UK Biobank Participants

A prospective cohort study of 428,207 UK Biobank participants over a median follow-up of 13.04 years, analyzing the association between the triglyceride-glucose (TyG) index and sepsis incidence and mortality. The dataset, authored by Shuying You and shared under a CC-BY-4.0 license, documents 12,410 sepsis events and 6,291 sepsis-related deaths. It stratifies results by diabetes status, finding a linear association in diabetic individuals but not in non-diabetic participants.

Use Cases

• Model sepsis risk stratification based on TyG index levels mentioned in the description
• Investigate effect modification by diabetes status based on the stratified analysis described
• Validate the TyG index as a predictive biomarker for sepsis-related mortality based on the reported hazard ratios
• Compare linear versus U-shaped associations of a biomarker with disease outcomes based on the findings for diabetic and non-diabetic subgroups

Strengths

• Large prospective cohort of 428,207 participants from the UK Biobank
• Long median follow-up period of 13.04 years
• Reports specific event counts: 12,410 sepsis events and 6,291 sepsis-related deaths
• Provides adjusted hazard ratios with 95% confidence intervals for associations

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 149.1 KB file size suggests the dataset is a summary table or document, not the raw underlying data

Provenance

Source

UK Biobank

Collection Method

Prospective cohort study with Cox proportional hazards modeling

Time Range

Median follow-up of 13.04 years

Freshness

Last updated 2026-05-28 04:50:48; freshness should be verified

Geography

United Kingdom