Umbilical Cord Vitamin D and Childhood Cardiometabolic Risk Associations

A Hong Kong-based longitudinal mother-child study from the HAPO cohort, investigating associations between umbilical cord vitamin D levels at birth and cardiometabolic risk factors in children around age 7. The dataset, authored by Di Mao and last updated in April 2026, contains results from linear regression analyses on clinical and biochemical parameters. It is a 32.6 KB document file.

Use Cases

• Modeling associations between neonatal vitamin D status and childhood diastolic blood pressure based on the reported negative correlation.
• Investigating links between cord blood vitamin D and arterial stiffness using the carotid-femoral pulse wave velocity (cfPWV) data.
• Analyzing the relationship between in-utero vitamin D exposure and childhood glucose metabolism based on fasting plasma glucose levels.
• Comparing the predictive value of maternal versus neonatal vitamin D measurements for later health outcomes.

Strengths

• Specific effect sizes are reported, such as a 0.73 mmHg reduction in diastolic BP per 18.0 nmol/L increase in cord vitamin D.
• Data is derived from a well-defined clinical cohort, the Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study.
• Analysis includes multiple cardiometabolic risk factors: blood pressure, arterial stiffness, lipid profile, and glucose/insulin.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The observational study design and modest effect size noted by the authors warrant cautious interpretation.

Provenance

Source

figshare, authored by Di Mao.

Collection Method

Archived serum samples from the HAPO Study Hong Kong Centre were assayed; children's clinical parameters were collected in a follow-up study.

Time Range

Maternal samples from 24–32 gestational weeks; child follow-up at around age 7.

Freshness

Last updated 2026-04-13 05:43:57; freshness should be verified.

Geography

Hong Kong.