Case Report on Atorvastatin-Almonertinib Drug Interaction and Myopathy

A case report details an 89-year-old male patient who developed myopathy with elevated creatine kinase (2,103 U/L) after concomitant use of atorvastatin and almonertinib. The report, authored by Jifang Zhou and published on figshare under CC-BY-4.0, describes the diagnosis and resolution after drug discontinuation. It concludes with recommendations for alternative cholesterol-lowering therapies in patients taking almonertinib.

Use Cases

• Analyzing adverse drug reaction patterns based on the described case of statin-induced myopathy.
• Studying pharmacokinetic interactions based on the CYP3A4 substrate mechanism described.
• Researching polypharmacy risks in elderly patients based on the patient's multiple medication history.

Strengths

• The report includes specific clinical values, such as a serum creatine kinase level of 2,103 U/L.
• It provides a detailed patient history, including medication durations (e.g., almonertinib for 26 months).
• The conclusion offers a specific therapeutic alternative (PCSK9 inhibitors).

Limitations

• The dataset is a single case report (72.8 KB PDF), representing a limited scope of evidence.
• Row count and column-level documentation are absent; data structure must be inferred from the narrative.
• The data may reflect a specific, isolated clinical event, limiting generalizability.

Provenance

Source

figshare

Collection Method

Clinical case documentation.

Freshness

Last updated 2026-05-14 04:26:37.