Life's Essential 8, Inflammation, and Gallstone Disease Risk in Chinese Adults

A cross-sectional study by Xinqiang Chen, published on figshare in June 2026, analyzes the association between cardiovascular health and gallstone disease. The dataset includes baseline survey data from 85,302 subjects in the China Multi-Ethnic Cohort (CMEC). It examines the mediating roles of inflammation and oxidative stress biomarkers in this relationship.

Use Cases

• Modeling the nonlinear dose-response relationship between Life's Essential 8 scores and gallstone disease risk.
• Investigating the mediating effects of inflammation and oxidative stress biomarkers on disease risk.
• Conducting subgroup analyses to identify population-specific protective effects, such as in individuals under 50, females, and Han ethnicity.
• Developing targeted public health interventions for gallstone disease prevention based on cardiovascular health metrics.

Strengths

• Includes data from a large cohort of 85,302 subjects.
• Reports a specific gallstone disease prevalence of 7.26% within the cohort.
• Provides quantified mediation proportions for inflammation (2.85%) and oxidative stress (5.21%).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the China Multi-Ethnic Cohort.

Provenance

Source

China Multi-Ethnic Cohort (CMEC) baseline survey data.

Collection Method

Cross-sectional study employing multivariate logistic regression, multiple linear regression, restricted cubic spline analysis, and mediation analysis.

Freshness

Last updated 2026-06-04 05:39:57; freshness should be verified.

Geography

China, multi-ethnic population.