Systematic Review of Mitochondrial Dysfunction and Synaptic Impairment in Schizophrenia

29 studies representing 2,847 participants were systematically reviewed, following PRISMA guidelines, to examine the link between mitochondrial bioenergetic dysfunction and synaptic impairment in schizophrenia. The review, authored by Valerio Ricci and last updated in March 2026, analyzed evidence from postmortem, neuroimaging, and molecular studies published from 2000 to 2025.

Use Cases

• Conducting meta-research on mitochondrial complex activity reductions (e.g., 18%–35% for complex I) based on the aggregated study findings.
• Analyzing correlations between ATP synthesis rates (20%–22% reductions) and cognitive deficits (r = 0.48) based on neuroimaging data.
• Investigating peripheral biomarkers like platelet complex I activity for disease specificity based on the described molecular studies.
• Studying regional specificity in prefrontal cortex and hippocampus for synaptic density reductions (27%) based on postmortem evidence.

Strengths

• Systematic methodology following PRISMA guidelines with 2,224 articles screened and a median quality score of 7/9 on the Newcastle-Ottawa Scale.
• Evidence synthesized from 29 studies across postmortem (n=10), neuroimaging (n=8), and molecular/cellular (n=11) investigations.
• Includes data from first-episode antipsychotic-naïve patients, suggesting findings relate to primary pathophysiology rather than medication effects.

Limitations

• The dataset is a 38.9 KB DOCX file containing a review article, not raw experimental data, limiting direct computational analysis.
• Substantial methodological heterogeneity across the 29 included studies precluded meta-analysis.
• Column-level documentation for any underlying data is absent; field semantics must be inferred from the review text.

Provenance

Source

figshare, authored by Valerio Ricci.

Collection Method

Systematic review following PRISMA guidelines, searching PubMed/MEDLINE, Embase, PsycINFO, and Web of Science.

Time Range

Studies published from 2000 to 2025.

Freshness

Last updated 2026-03-18 07:40:37.

Geography

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