Bitter Gourd Peptide Effects on Spinal Cord Injury in Cell and Rat Models

Experimental data from a study investigating the neuroprotective effects of Bitter Gourd Bioactive Peptide (BGBP) on spinal cord ischemia-reperfusion injury. The dataset likely contains measurements from in vitro BV-2 microglial cell and in vivo rat models, including cell viability, oxidative stress markers, ferroptosis indicators, and motor function scores. The data was authored by Qiyang Diao and shared under a CC-BY-4.0 license on figshare in May 2026.

Use Cases

• Analyze the relationship between BGBP treatment and cell viability based on the in vitro chemical hypoxia model.
• Investigate the effect of BGBP on oxidative stress markers like ROS, MDA, and SOD levels described in the methods.
• Study the modulation of ferroptosis indicators (Fe2+, GSH, GPX4) by BGBP treatment in the context of SCIRI.
• Correlate Nrf2/HO-1 pathway activation data with observed neuroprotection and motor function recovery in the rat model.
• Validate the combined CoCl2-induced cell model and rat abdominal aortic clamping model as a platform for studying ferroptosis-targeted neuroprotection.

Strengths

• Data is derived from a dual-model experimental design combining in vitro and in vivo approaches.
• Specific treatment concentrations and dosages are provided (1.6 mg/mL in vitro; 50 mg/kg orally in vivo).
• A wide range of biological endpoints were measured, including molecular, cellular, and functional outcomes.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (18.0 KB), indicating limited scope, likely summarizing results rather than containing raw experimental data.

Provenance

Source

figshare

Collection Method

Data was generated from laboratory experiments using BV-2 microglial cells and a rat model of spinal cord ischemia-reperfusion injury.

Freshness

Last updated 2026-05-11 04:25:38; freshness should be verified.