BKI-1748 Efficacy Against Ovine Congenital Toxoplasmosis After IgM Seroconversion

23 pregnant sheep were orally inoculated with Toxoplasma gondii oocysts at 90 days of gestation. The study, authored by Roberto Sánchez-Sánchez and last updated in April 2026, reports that treatment with BKI-1748 starting 14 days post-infection resulted in 91% viable lambs in treated animals versus 52% in untreated controls.

Use Cases

• Evaluating drug efficacy for congenital toxoplasmosis based on lamb viability and infection rates.
• Analyzing serological response patterns based on IgG level reductions in treated subjects.
• Modeling prenatal treatment timelines based on intervention initiated after IgM seroconversion.

Strengths

• Results include specific efficacy metrics: 91% lamb viability in treated group vs. 52% in untreated group.
• Study design details are provided, including a treatment group of 10 sheep and a control group of 10.

Limitations

• The dataset is a 261.8 KB DOCX document; the underlying tabular data structure and column definitions are unknown.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Roberto Sánchez-Sánchez via figshare

Collection Method

Experimental study involving oral inoculation of pregnant sheep and subsequent drug treatment.

Freshness

Last updated 2026-04-27 05:18:20; freshness should be verified.