PP1 Analogs: Cellular Effects on Non-Tumoral and Tumoral Cell Lines

A dataset from figshare by Coralie Gicquel, last updated in April 2026, examining the cellular effects of five bulky PP1 analog inhibitors. The 14.8 KB Excel file likely contains experimental results on cell migration, invasion, proliferation, cell cycle, viability, and differentiation. The work investigates the specificity of these chemical genetics tools at concentrations as low as 2 µM.

Use Cases

• Assessing off-target effects of PP1 analogs based on described cellular processes like migration and proliferation.
• Comparing inhibitor specificity based on the five analog compounds mentioned in the description.
• Determining safe concentration thresholds for chemical genetics studies based on the described non-specific effects at ≥5 µM.
• Investigating cell line responses to kinase inhibitors based on the described non-tumoral and tumoral cell models.

Strengths

• Data is shared under a permissive CC-BY-4.0 license.
• The description provides specific context about the five inhibitors and their tested cellular effects.
• The dataset is small (14.8 KB), facilitating quick download and inspection.

Limitations

• Row count and column definitions are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's scale is limited to 14.8 KB, indicating a small experimental dataset.

Provenance

Source

figshare, author Coralie Gicquel.

Collection Method

Likely contains experimental results from cell biology assays as described.

Freshness

Last updated 2026-04-28 10:21:03; freshness should be verified.