Table 1_Bushen Huoxue recipe restores trophoblast proliferation through the PI3K/AKT pathw

155 chemical constituents of the Traditional Chinese Medicine formula Bushen Huoxue Recipe were identified via UPLC–Q–TOF–MS/MS. The dataset includes transcriptome sequencing and network pharmacology results linking the formula to 267 therapeutic targets and the PI3K/AKT pathway, supported by mouse miscarriage model data. Authored by Jingheng You and last updated on 2026-04-21, this 41.9 KB document is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validate network pharmacology predictions linking herbal compounds to the PI3K/AKT pathway based on the identified 155 constituents and 267 targets.
• Analyze transcriptomic signatures of recurrent spontaneous abortion (RSA) based on the described sequencing results.
• Correlate molecular pathway activation with clinical outcomes like embryo loss rate and hormone levels based on the described mouse model experiments.
• Investigate the proliferative effect of a Traditional Chinese Medicine formula on trophoblast cells based on the described Ki67 and PCNA protein expression data.

Strengths

• Identifies 155 specific chemical constituents within the herbal formula.
• Links the formula's effects to 267 potential therapeutic targets for recurrent spontaneous abortion.
• Integrates multiple analysis methods: UPLC–Q–TOF–MS/MS, transcriptome sequencing, network pharmacology, and in vivo mouse model validation.

Limitations

• The dataset is a 41.9 KB DOCX file, suggesting limited raw data and likely consisting of summarized results or a manuscript.
• Row and column structures are unknown, and no sample data is available, limiting direct computational analysis.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Jingheng You.

Collection Method

Data generated through UPLC–Q–TOF–MS/MS, transcriptome sequencing, network pharmacology, and in vivo experiments on a mouse miscarriage model.

Freshness

Last updated 2026-04-21 05:36:18; freshness should be verified.