Table 1_Cadmium chloride and erectile dysfunction: integrative evidence from network toxic

A 29.7 KB DOCX file by Yuqi Li, last updated April 2026, presents research investigating the link between cadmium chloride exposure and erectile dysfunction. The study employs an integrated framework of network toxicology, Mendelian randomization analysis, and in vitro validation using human umbilical vein endothelial cells. It identifies estrogen receptor 2 (ESR2) as a key mediating gene and demonstrates a causal association with increased ED risk.

Use Cases

• Training models to identify gene-disease associations based on network toxicology methods described.
• Analyzing causal relationships between environmental exposures and health outcomes using Mendelian randomization techniques.
• Studying concentration- and time-dependent effects of toxicants on cell viability, as demonstrated in the in vitro experiments.
• Investigating the role of specific genes like ESR2 in mediating the effects of heavy metals on vascular endothelial function.

Strengths

• Employs a multi-method framework integrating computational, genetic, and experimental validation.
• Identifies a specific gene (ESR2) as a key mediator, providing a concrete molecular target.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and distribution.

Limitations

• The 29.7 KB size indicates the file likely contains a research paper summary, not a primary dataset with rows and columns.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for data-driven modeling.

Provenance

Source

figshare, authored by Yuqi Li.

Collection Method

Integrated analysis using databases (PubChem, TargetNet, GeneCards, STRING), Mendelian randomization, and in vitro cell experiments.

Time Range

Study period not specified; publication date is 2026.

Freshness

Last updated 2026-04-15 04:37:00; freshness should be verified.

Geography

Spatial coverage is not specified.