Table 1_Caffeine-mediated CD39+ Treg activation via the CD39-adenosine receptor pathway is

A research dataset presents results from a multi-method study investigating the causal link between caffeine and pulmonary tuberculosis (PTB). The analysis includes two-sample Mendelian randomization for 486 metabolites and 731 immune cells, integrated single-cell and bulk RNA sequencing of PTB lungs, and experimental validation. The 2.0 MB Excel file was authored by Liangyu Zhu and last updated on April 20, 2026.

Use Cases

• Validate the causal link between caffeine and PTB risk based on Mendelian randomization results for eight metabolites and nine immune subsets.
• Investigate CD39+ Treg activation mechanisms in PTB lungs using single-cell RNA sequencing data referenced in the description.
• Assess the diagnostic potential of core genes PSMC5, BAG1, and AGPAT5 for PTB based on reported differential expression and AUC > 0.7.
• Explore the CD39-adenosine receptor pathway as a novel immunological mechanism connecting metabolite exposure to disease risk.

Strengths

• Results are derived from a multi-tiered methodology combining Mendelian randomization, single-cell RNA-seq, and experimental validation in multiple models.
• Specific statistical thresholds are reported, such as P < 0.05 for identified metabolites and a 10.4% mediated proportion for caffeine's effect.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The description is detailed on methodology but does not specify the exact data structure or variables contained in the Excel file.

Provenance

Source

figshare

Collection Method

Analysis results from Mendelian randomization, single-cell RNA sequencing, and experimental validation in cell lines, mice, and patient samples.

Freshness

Last updated 2026-04-20 04:13:26; freshness should be verified.