Case Report: A 47-Year Tonsillar Carcinoma Trajectory with Molecular Data

A single, detailed case report documents an extremely rare 47-year clinical course of tonsillar adenoid cystic carcinoma. The report, authored by Mingzhu Wang and shared on figshare, includes a timeline from 1977 to 2024 and molecular profiling data from a 2018 recurrence. This case highlights the potential for decades of indolent disease before late progression.

Use Cases

• Analyzing long-term survival patterns in rare head and neck cancers based on the detailed 47-year timeline.
• Studying the transition from indolent to aggressive disease based on the described clinical progression phases.
• Investigating genomic markers like NOTCH2, MTOR, and SPEN in adenoid cystic carcinoma based on the reported molecular profiling.
• Developing case studies for medical education based on the comprehensive clinical history and treatment responses.

Strengths

• Includes molecular profiling data (NOTCH2, MTOR, SPEN) from a 2018 recurrence.
• Documents an exceptionally long 47-year clinical course from 1977 to 2024.
• Provides a detailed, longitudinal case history including treatment modalities and outcomes.

Limitations

• Dataset is a single case report (N=1), limiting statistical analysis and generalizability.
• Row count and column-level documentation are absent; data structure must be inferred from the narrative.
• The 24.2 KB file size indicates a very limited scope, likely containing only the report text.

Provenance

Source

figshare

Collection Method

Clinical case documentation and molecular analysis.

Time Range

1977 to 2024

Freshness

Last updated 2026-06-02 04:28:47