CIRC Tumor Case Report: Genomic and Immunohistochemistry Data

Wen Liu's case report details genomic and immunohistochemical data from a 67-year-old female with a recurrent Cytokeratin-positive interstitial reticulum cell tumor. The dataset includes whole-exome sequencing results identifying 30 single-nucleotide variants, 7 indels, copy number gains, and the first reported HLA loss of heterozygosity events in this tumor type. It was last updated on June 2, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Study immune evasion mechanisms in rare tumors based on the reported HLA loss of heterozygosity events.
• Analyze genomic instability in fibroblastic reticular cell tumors based on the reported copy number gains and variant data.
• Correlate immunohistochemical marker expression with tumor pathology based on the described staining profile for cytokeratins, CD68, and other markers.

Strengths

• Includes detailed whole-exome sequencing results with 30 single-nucleotide variants and 7 indels.
• Provides comprehensive immunohistochemistry results for over 15 markers.
• Documents the first reported case of HLA loss of heterozygosity in this specific rare tumor subtype.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single case report with a file size of 20.0 KB, representing a very limited scope.

Provenance

Source

Wen Liu, via figshare.

Collection Method

Data appears to be derived from a clinical case study, including histology, immunohistochemistry, and whole-exome sequencing.

Freshness

Last updated 2026-06-02 04:21:00; freshness should be verified.