KMT2A Amplification in B-Cell Leukemia: Two Adult Case Reports

Two adult case reports detail the rare occurrence of KMT2A gene amplification in B-cell acute lymphoblastic leukemia (B-ALL), a genetic alteration present in less than 1% of cases. The data, authored by Min Gao and published on figshare in March 2026, includes clinical and genetic details for two patients, aged 58 and 66, with associated TP53 variants and CRLF2 rearrangement. This 16.5 KB document is supplemented by a review of nine additional published cases, highlighting the aggressive nature of this leukemia subtype.

Use Cases

• Study the co-occurrence of KMT2A amplification with TP53 variants based on the described patient cases
• Analyze the clinical presentation and outcomes of rare KMT2A-amplified B-ALL based on the reported patient histories
• Investigate the association between KMT2A amplification and CRLF2 rearrangement mentioned in the second case
• Review genetic characteristics for risk stratification in adult B-ALL based on the aggregated case data

Strengths

• Includes specific genetic copy numbers (6-18 copies, 8-11 copies) and cell percentages (68.5%, 87.5%) for the two cases
• Provides detailed patient demographics (age, sex) and clinical outcomes
• Integrates findings with a review of nine additional published cases for context
• Released under a permissive CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (16.5 KB), representing only two primary case reports

Provenance

Source

figshare

Collection Method

Clinical case report and literature review

Freshness

Last updated 2026-03-18 07:34:18; freshness should be verified