Canine Post-Stroke Hemorrhagic Infarction Case Report

A 652.3 KB veterinary case report details the acute neuropathology of a 4.5-year-old male Beagle with status epilepticus and a simultaneous post-stroke hemorrhagic infarction. The report, authored by Nikita M. Joshi, includes clinical course, hematobiochemistry, treatment, and histopathological findings, reinforcing the role of VEGF-A-driven angiogenesis in acute canine epilepsy.

Use Cases

• Analyze the relationship between serum creatine kinase and aspartate aminotransferase levels and severe muscular exertion in a canine neurological case.
• Study the histopathological features of multifocal thrombosis and liquefactive necro-hemorrhagic foci in post-stroke canine brain tissue.
• Investigate VEGF-A and reticulin expression in newly formed peri-infarct vessels as markers of acute inflammatory extracellular matrix changes.
• Correlate clinical observations like absolute monocytosis and neutropenia with the described systemic neuroinflammatory response.

Strengths

• Provides a detailed, single-subject case report spanning the full clinical course, treatment, and post-mortem examination.
• Includes specific quantitative laboratory findings, such as a 30% decline in serum albumin levels and marked enzyme elevations.
• Contains histopathological confirmation of multifocal lesions and specific protein expression (VEGF-A, reticulin) analysis.

Limitations

• The dataset is a single case report (n=1), limiting statistical analysis and generalizability.
• Data is presented in a narrative DOCX format, not structured tabular data, requiring manual extraction for computational analysis.
• Findings are specific to a single 4.5-year-old male Beagle, which may not represent other breeds, ages, or sexes.

Provenance

Source

figshare, author Nikita M. Joshi.

Collection Method

Clinical case observation and post-mortem histopathological analysis of a single patient.

Time Range

Covers a 5-day clinical course prior to necropsy.

Freshness

null

Geography

null