Case Report: Serum IgG4-Negative Hepatic Inflammatory Pseudotumor

Wei Wang authored a case report describing a 60-year-old male patient with multifocal IgG4-related hepatic inflammatory pseudotumor despite normal serum IgG4 levels. The report details clinical presentation, imaging findings, histopathological analysis, and treatment response. The document was uploaded to figshare in April 2026 and is licensed under CC-BY-4.0.

Use Cases

• Analyzing the dissociation between serum biomarkers and local tissue pathology based on the described case of normal serum IgG4 with positive tissue infiltration.
• Studying imaging features of benign liver lesions that mimic malignancy based on described arterial enhancement, diffusion restriction, and PET/CT activity.
• Investigating treatment response in immune-mediated fibroinflammatory disorders based on the reported radiologic regression following corticosteroid therapy.
• Supporting diagnostic criteria development for IgG4-related disease based on the histopathological findings of lymphoplasmacytic infiltration, storiform fibrosis, and obliterative phlebitis.

Strengths

• The report provides a detailed clinical narrative including patient age (60), symptoms, and specific imaging modalities (arterial phase enhancement, peripheral rim enhancement, diffusion restriction, ^18F-FDG PET/CT).
• Includes definitive histopathological findings (dense IgG4-positive lymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis) that established the diagnosis.
• Documents a clear treatment outcome (marked radiologic regression following corticosteroid therapy).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single case report (16.9 KB), representing a very limited scope.

Provenance

Source

Wei Wang via figshare

Collection Method

Clinical case documentation and analysis.

Time Range

Case report timeframe is unspecified.

Freshness

Last updated 2026-04-15 05:44:10; freshness should be verified.

Geography

Geographic origin of the case is unspecified.